What is lansoprazole?
Lansoprazole is a proton pump inhibitor (PPI) for the treatment of sodburns, gastroesophageal reflux disease (GERD) and gastrointestinal/intestinal ulcers. It is available under the brand name Agopton® and as a generic.
Lansoprazole is characterized by a somewhat faster impact than other PPIs. It is available as a capsule and as a melt tablet (orodispersible), which makes it easier to take with swallowing problems.
Like all PPIs, Lansoprazol inhibits gastric acid production and is used for short and long-term treatment of acid-related diseases.
Active Ingredients & Mechanism of Action
Active ingredient: Lansoprazol
Lansoprazole irreversibly inhibits the proton pump of the gastric insert cells:
Active mechanism:
- Prodrug, activated in the acid medium of the document cell
- Irreversible binding to H+/K+-ATPase
- Blocks acid production in the last step
- Reduction of gastric acid by up to 90%
Special features:
- A little faster than omeprazole
- High bioavailability
- half-life approx. 1-2 hours, but working time 24+ hours
Who is it suitable for?
Lansoprazole is suitable for:
- Gastroesophageal reflux disease (GERD)
- Refluxeophagitis
- Gastrointestinal ulcers
- Helicobacter-pylori-Eradikation
- Gastric protection at NSAID intake
- Zollinger-Ellison Syndrome
- Patients with swallowing complaints (melting tablet available)
Not suitable:
- In case of unclear structural problems without diagnosis
- As long-term therapy without medical indication
Available Dosages
Available starches:
- 15 mg capsules/melt tablets
- 30 mg capsules/melt tablets
Other dosages:
- Sodburning/light reflux: 15-30 mg 1x daily
- Refluxesophagitis: 30 mg 1x daily for 4-8 weeks
- Gastric ulcer: 30 mg 1x daily for 4 weeks
- 12-fingered ulcer: 30 mg 1x daily for 2-4 weeks
- Helicobacter Eradication: 30 mg 2x daily (with antibiotics)
- Maintenance: 15 mg 1x per day
How to Take
Intake:
- Morning, 30 minutes before breakfast
- Capsules unzerkaut swallow
Small tablet (FasTab):
- Put on the tongue and disintegrate
- Removable without water
- Ideal for slippers
**
- Regularly take, not only in case of complaints
- Do not drop abruptly after long-term therapy
- Regular medical check for permanent use
Contraindications
**Lansoprazole must not be taken at:* *
- hypersensitivity to lansoprazole or other PPIs
- Simultaneous intake of Atazanavir or Nelfinavir
Preview at:
- liver failure (max. 30 mg, monitor liver values)
- Long-term application (standard risks of PPI class)
- Suspicion of stomach cancer
Pregnant period: Only with urgent indication. Limited data.
Possible Side Effects
Acid (1-10%):
- Headaches
- Squeeze
- diarrhea
- nausea
- stomach pain
- Blocking
- Blowing
Occasionally:
- Skin rash
- Mouth dryness
- joint pain
- fatigue
Long-term risks (all PPIs):
- Magnesium deficiency
- Vitamin B12 deficiency
- Increased fracture risk
- Clostridium difficile infection risk
Interactions
Reduced absorption by pH increase:
- Ketoconazole, Itraconazole
- Iron preparations, vitamin B12
- Atazanavir, Nelfinavir (contrained)
Lansoprazole inhibits CYP2C19 (moderate):
- Interaction potential between omeprazole and pantoprazole
- Caution in Clopidogrel (Pantoprazole may prefer)
Theophyllin: Accelerated elimination possible. Control mirrors.
Frequently Asked Questions
Similar Medications
Is lansoprazole right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor. Read the package leaflet before use.