What is spices?
Spedra is a modern drug for treating erectile dysfunction with the active ingredient Avanafil. It was approved in 2013 and is the newest PDE-5 inhibitor on the market.
The special feature of Spedra is the very rapid action: In some men, the drug already acts after 15 minutes – significantly faster than all other PDE-5-inhibitors. This allows maximum spontaneity.
Spedra was developed from the outset with the aim of working faster and causing fewer side effects. The active ingredient Avanafil is highly selective for PDE-5 and influences other enzymes less than older active ingredients of this class.
The drug is Prescription and is distributed by Menarini.
Active Ingredients & Mechanism of Action
Active ingredient: Avanafil
Avanafil belongs to the group of PDE-5 inhibitors, but because of its chemical structure it acts particularly fast and selective.
The mechanism: In sexual excitation, nitrogen monoxide (NO) is released which activates the production of cGMP. cGMP relaxes the blood vessels in the penis, more blood flows in, an erection arises.
The enzyme PDE-5 removes cGMP. Avanafil inhibits this enzyme so that cGMP works longer and the erection is supported.
Why Avanafil acts as fast: The chemical structure of Avanafil allows for rapid intake into the blood and rapid action. Unlike older PDE 5 inhibitors, the effect can be noticeable after 15 minutes.
High selectivity: Avanafil is particularly selective for PDE-5. It affects other PDE enzymes (which occur, for example, in the eyes or in the cardiovascular system) less than Sildenafil. This could lead to fewer side effects.
Who is it suitable for?
Spedra is suitable for men who:
Maximum spontaneity wish:
- Admission possible shortly before intercourse (15-30 min.)
- No long planning required
- Ideal for unplanned intimate moments
Welcome side effects:
- High selectivity can lead to better compatibility
- Less visual disorders than Sildenafil
- Maybe less headaches
**Other PDE-5-Hemmer not tolerate optimally:* *
- Alternative incompatibility
- Different side effect profile
Typical indications:
- Erectile dysfunction of various causes
- Organic, psychological or mixed ED
- diabetics with erection problems
Available Dosages
available dosages:
- 50 mg – lowest dose
- 100 mg – Recommended initial dose
- 200 mg – Maximum single dose
Dosing recommendations:
- Standard: 100 mg about 15-30 minutes before sexual intercourse
- For good effect: Can stay at 100 mg
- In case of insufficient effect: Increase to 200 mg
- For severe side effects: reduction to 50 mg
Older men: No routine dose adjustment required.
Maximaldosis: 200 mg per day, not more often than once a day
How to Take
Intake:
- About 15-30 minutes before scheduled intercourse
- With a glass of water
- With or without food possible
- Very high-fat meals can easily delay the impact
* *The advantage of fast action:** With Spedra you don't have to plan as long in advance as with other potency means. In most men it works within 15-30 minutes – sometimes even faster.
Activity: The effect lasts about 6-12 hours. In this period, erections are possible for sexual stimulation.
Activity: Maximum one dose per 24 hours.
Alcohol: Moderate alcohol consumption is possible. However, excessive alcohol can reduce the effectiveness.
Contraindications
Absolute contraindications:
- Nitrate intake: Combination with nitrates or amyl nitrite is strictly contraindicated due to risk of severe blood pressure drop
- Black heart disease: Heart attack in the last 6 months, unstable angina pectoris, severe heart failure
- Slow blood pressure (under 90/50 mmHg)
- Uncontrolled hypertension (over 170/100 mmHg)
- **Short stroke * *
- Smooth liver failure
- **Some retinal diseases * *
- Further CYP3A4 inhibitors (Ketoconazole, Ritonavir, etc.)
Preview at:
- Anatomical penis deformities
- Disorders with Priapism Risk
- Moderate liver or kidney failure
Possible Side Effects
**Family side effects (1-10%):* *
- Headaches
- Face redness (Flush)
- Blocked nose
** Occasionally (0,1-1%):* *
- Squeeze
- Back pain
- Heat sensation
- Nose nebula symptoms
- Indigestion
Selten, but seriously:
- Priapism: Painful erection over 4 hours – immediately medical help
- Sold visual loss: Immediately to the doctor
- Sold hearing loss:
* *Compared:** As a result of the high selectivity of Avanafil, visual disorders (blue sluice) occur less frequently than in Sildenafil. Headaches also seem to be a little less rare in studies.
Interactions
Absolute contraindicated:
- Nitrate and NO donors: Life-threatening blood pressure drop
- Starke CYP3A4 inhibitor: Ketoconazole, Itraconazole, Ritonavir (contraindication)
Important interactions:
- Moderate CYP3A4 inhibitor (erythromycin, fluconazole): maximum dose 100 mg in 24 hours
- Alpha blocker: Blood pressure reduction possible, lowest dose start
- Blow pressure media: Additives low blood pressure
- Other PDE-5-Hemmer: No combination
- Grapefruit juice: Can increase Avanafil levels easily
Frequently Asked Questions
Similar Medications
Is spices right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor. Read the package leaflet before use.